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Clinical experience with 13C MRS in vivo

✍ Scribed by Brian Ross; Alexander Lin; Kent Harris; Pratip Bhattacharya; Brian Schweinsburg

Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
380 KB
Volume
16
Category
Article
ISSN
0952-3480

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✦ Synopsis

Abstract

^13^C MRS was installed on a clinical scanner at 1.5 T in order to facilitate integrated MR examinations of human brain disorders. Using a simplified protocol, (1‐^13^C) glucose and/or (1‐^13^C) acetate were administered orally or by intravenous infusion. ^13^C spectra of diagnostic quality were acquired in more than 100 consecutive studies. Novel ^13^C neurochemical data contributed to the understanding of Alzheimer's, Canavan's, mitochondrial and hepatic encephalopathy, epilepsy and normal brain development. ^13^C MRS uncovered hitherto unknown disorders of NAA‐synthesis, glutamate neurotransmission, TCA‐cycle and glycolysis. Despite low inherent signal‐to‐noise, natural abundance ^13^C MRS showed diagnostic promise. ^13^C MRS is feasible in a clinical setting, at reasonable cost in neonates, children, adults and elderly patients. Copyright Β© 2003 John Wiley & Sons, Ltd.

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