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Clinical evaluation of tocilizumab for patients with active rheumatoid arthritis refractory to anti-TNF biologics: tocilizumab in combination with methotrexate

✍ Scribed by Yasuharu Nakashima; Masakazu Kondo; Hiroshi Harada; Takahiko Horiuchi; Takashi Ishinishi; Hiroshi Jojima; Koji Kuroda; Hisaaki Miyahara; Ryuji Nagamine; Hitoshi Nakashima; Takeshi Otsuka; Isao Saikawa; Eisuke Shono; Eiichi Suematsu; Tomomi Tsuru; Ken Wada; Yukihide Iwamoto


Publisher
Springer
Year
2010
Tongue
English
Weight
348 KB
Volume
20
Category
Article
ISSN
1439-7595

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✍ Patrick Garnero; Elizabeth Thompson; Thasia Woodworth; Josef S. Smolen 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 276 KB 👁 3 views

## Abstract ## Objective To investigate the effects of tocilizumab (TCZ) added to a stable dosage of methotrexate (MTX) on biochemical markers of bone and cartilage metabolism in patients in the multicenter double‐blind, placebo‐controlled OPTION (Tocilizumab Pivotal Trial in Methotrexate Inadequa