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Double-blind randomized controlled clinical trial of the interleukin-6 receptor antagonist, tocilizumab, in European patients with rheumatoid arthritis who had an incomplete response to methotrexate

✍ Scribed by R. N. Maini; P. C. Taylor; J. Szechinski; K. Pavelka; J. Bröll; G. Balint; P. Emery; F. Raemen; J. Petersen; J. Smolen; D. Thomson; T. Kishimoto


Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
320 KB
Volume
54
Category
Article
ISSN
0004-3591

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## Abstract ## Objective To investigate the effects of tocilizumab (TCZ) added to a stable dosage of methotrexate (MTX) on biochemical markers of bone and cartilage metabolism in patients in the multicenter double‐blind, placebo‐controlled OPTION (Tocilizumab Pivotal Trial in Methotrexate Inadequa