Clinical Evaluation of Antitumor Therapy

✍ Scribed by Franco M. Muggia, Marcel Rozencweig (auth.), Franco M. Muggia M.D., Marcel Rozencweig M.D. (eds.)

• Publisher: Springer US
• Year: 1986
• Tongue: English
• Leaves: 223
• Series: Developments in Oncology 46
• Edition: 1
• Category: Library

✦ Synopsis

The methodology of drug development has been the subject of extensive dis­ cussion by a relatively small group of individuals in industry and government who have been intimately concerned with the identification and study of new anticancer drugs. The Chemotherapy Program of the National Cancer In­ stitute has represented the major focus of initial efforts in drug development, as summarized in the historical perspective presented in chapter 1 and its references. It is no coincidence that the Chemotherapy Program was the origin of the Division of Cancer Treatment, a government entity that has had a pivotal role in the growth of clinical oncology. In an analogous fashion this book presents the methodology employed in the clinical study of anticancer drugs within the broad context of cancer treatment. The research orientation promulgated in the study of new drugs is a central theme in most oncolo­ gists' approach to the clinical problem of cancer. Therefore, we hope that this book will introduce readers to treatment research in clinical oncology. For the oncologist, the clinical evaluation of antitumor therapy is both part of the day-to-day management of specific patients and the critical considera­ tion of developing therapeutic alternatives. For physicians in other fields of medicine it is important to acquaint themselves with the basic tools of the oncologist. For people without medical training, including patients who might be interested in treatment research, many of the chapters may be overly technical.

✦ Table of Contents

Front Matter....Pages i-xii
General Issues in Anticancer Drug Development....Pages 3-16
Animal Tumor Models for Experimental Therapy....Pages 17-31
Experimental Therapy: In Vitro Models....Pages 33-53
Clinical Evaluation: Noninvasive Methods....Pages 55-83
Clinical Evaluation: Biochemical Methods....Pages 85-115
Anatomic and Surgical Principles in Cancer Clinical Trials....Pages 117-131
Experimental Toxicology....Pages 133-152
The Phase I Study: General Objectives, Methods, and Evaluation....Pages 153-174
Clinical Evaluation of Anticancer Treatments: Phase II Clinical Trials....Pages 175-197
Analysis of Clinical Trial Data....Pages 199-210
The Strategy of Cancer Treatment....Pages 211-216
Back Matter....Pages 217-219

✦ Subjects

Oncology