Clinical efficacy of YM-09151, a new benzamide derivative, on schizophrenia
β Scribed by Y. Kudo; G. Ikawa; Y. Kawakita; M Saito; T. Sakai; T. Nakajima; T. Nishimura; Y. Higashi; K. Hitomi
- Book ID
- 115885337
- Publisher
- Elsevier Science
- Year
- 1990
- Tongue
- English
- Weight
- 117 KB
- Volume
- 183
- Category
- Article
- ISSN
- 0014-2999
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## Abstract A new potent neuroleptic agent YMβ09151β2, Nβ[(2RS, 3RS)β1βbenzylβ2βmethylβ3βpyrrolidinyl]β5βchloroβ2βmethoxyβ4β (methylamino) benzamide (**10c**), was labeled with carbonβ14 and deuterium for biochemical studies such as metabolism and 14 pharmacokinetics. The synthesis of [carbonylβ^14
Effects of YM-14673 (N alpha-[[S)-4-oxo-2-azetidinyl)-carbonyl]-L-histidyl-L-prolinamide dihydrate), a new TRH derivative, on reserpine-induced behavioural and electroencephalographic changes were observed in comparison with those of TRH. YM-14673 antagonized reserpine-induced hypothermia and decrea