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Clinical efficacy of 5-fluorouracil (5-FU) topical cream for treatment of cholesteatoma

✍ Scribed by Haruo Takahashi; Kazuo Funabiki; Seishi Hasebe; Tomomi Fukuda-Yamamoto; Satoru Kaieda; Tetsu Iwanaga; Hidetaka Kumagami; Kenji Takasaki

Book ID
116223244
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
279 KB
Volume
32
Category
Article
ISSN
0385-8146

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Topical delivery of 5-fluorouracil (5-FU
Topical delivery of 5-fluorouracil (5-FU) by 3-alkylcarbonyloxymethyl-5-FU prodrugs
✍ William J. Roberts; Kenneth B. Sloan πŸ“‚ Article πŸ“… 2003 πŸ› John Wiley and Sons 🌐 English βš– 110 KB

The 3-alkylcarbonyloxymethyl-5-fluorouracil (3-ACOM-5-FU) prodrugs have been characterized by their solubilities in isopropyl myristate (S(IPM)) and partition coefficients between IPM and pH 4.0 buffer (K(IPM:AQ)). Estimated S(AQ) values have been obtained from S(AQ) = S(IPM)/K(IPM:AQ.) The abilitie