Topical delivery of 5-fluorouracil (5-FU
โ
William J. Roberts; Kenneth B. Sloan
๐
Article
๐
2003
๐
John Wiley and Sons
๐
English
โ 110 KB
The 3-alkylcarbonyloxymethyl-5-fluorouracil (3-ACOM-5-FU) prodrugs have been characterized by their solubilities in isopropyl myristate (S(IPM)) and partition coefficients between IPM and pH 4.0 buffer (K(IPM:AQ)). Estimated S(AQ) values have been obtained from S(AQ) = S(IPM)/K(IPM:AQ.) The abilitie