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Topical delivery of 5-fluorouracil (5-FU) by 1,3-bisalkylcarbonyl-5-FU prodrugs

โœ Scribed by Howard D Beall; Kenneth B Sloan


Book ID
108454030
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
87 KB
Volume
231
Category
Article
ISSN
0378-5173

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Topical delivery of 5-fluorouracil (5-FU
โœ William J. Roberts; Kenneth B. Sloan ๐Ÿ“‚ Article ๐Ÿ“… 2003 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 110 KB

The 3-alkylcarbonyloxymethyl-5-fluorouracil (3-ACOM-5-FU) prodrugs have been characterized by their solubilities in isopropyl myristate (S(IPM)) and partition coefficients between IPM and pH 4.0 buffer (K(IPM:AQ)). Estimated S(AQ) values have been obtained from S(AQ) = S(IPM)/K(IPM:AQ.) The abilitie