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Clinical development of anti-RANKL therapies for treatment and prevention of bone metastasis

✍ Scribed by Allan Lipton; Carsten Goessl

Book ID
116324081
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
279 KB
Volume
48
Category
Article
ISSN
8756-3282

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## Abstract Focal bone loss around inflamed joints in patients with autoimmune disease, such as rheumatoid arthritis, remains a serious clinical problem. The recent elucidation of the RANK/RANK‐ligand/OPG pathway and its role as the final effector of osteoclastogenesis and bone resorption has broug