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Clinical consequences of molecular diagnosis in families with mismatch repair gene germline mutations

✍ Scribed by Steffen R. Pistorius; Christian Kruppa; Stephan Haas; Jens Plaschke; Stefan Kruger; Clemens J. Bulitta; Michael Nagel; Hans-Detlev Saeger; Hans K. Schackert

Book ID: 106060414
Publisher: Springer
Year: 2000
Tongue: English
Weight: 109 KB
Volume: 15
Category: Article
ISSN: 0179-1958
DOI: 10.1007/s003840000261

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## Abstract Lynch syndrome is defined by the presence of germline mutations in mismatch repair (MMR) genes. Several models have been recently devised that predict mutation carrier status (Myriad Genetics, Wijnen, Barnetson, PREMM and MMRpro models). Families at moderate‐high risk for harboring a Ly