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Clinical Applications for Next-Generation Sequencing

✍ Scribed by Demkow, Urszula; Ploski, Rafal

Publisher
Academic Press
Year
2016
Tongue
English
Leaves
316
Edition
1
Category
Library
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✦ Synopsis

Clinical Applications for Next Generation Sequencing provides readers with an outstanding postgraduate resource to learn about the translational use of NGS in clinical environments.

Rooted in both medical genetics and clinical medicine, the book fills the gap between state-of-the-art technology and evidence-based practice, providing an educational opportunity for users to advance patient care by transferring NGS to the needs of real-world patients.

The book builds an interface between genetic laboratory staff and clinical health workers to not only improve communication, but also strengthen cooperation. Users will find valuable tactics they can use to build a systematic framework for understanding the role of NGS testing in both common and rare diseases and conditions, from prenatal care, like chromosomal abnormalities, up to advanced age problems like dementia.

  • Fills the gap between state-of-the-art technology and evidence-based practice
  • Provides an educational opportunity which advances patient care through the transfer of NGS to real-world patient assessment
  • Promotes a practical tool that clinicians can apply directly to patient care
  • Includes a systematic framework for understanding the role of NGS testing in many common and rare diseases
  • Presents evidence regarding the important role of NGS in current diagnostic strategies

✦ Table of Contents

Content:
Front Matter,Copyright,List of ContributorsEntitled to full textChapter 1 - Next Generation Sequencing—General Information about the Technology, Possibilities, and Limitations, Pages 1-18, Rafał Płoski
Chapter 2 - Basic Bioinformatic Analyses of NGS Data, Pages 19-37, Piotr Stawinski, Ravi Sachidanandam, Izabela Chojnicka, Rafał Płoski
Chapter 3 - Analysis of Structural Chromosome Variants by Next Generation Sequencing Methods, Pages 39-61, Dariusz Plewczynski, Sławomir Gruca, Przemysław Szałaj, Krystian Gulik, Silviene Fabiana de Oliveira, Ankit Malhotra
Chapter 4 - Next Generation Sequencing in Oncology, Pages 63-74, Eliza Glodkowska-Mrowka, Tomasz Stoklosa
Chapter 5 - Next Generation Sequencing in Hematological Disorders, Pages 75-96, Iwona Malinowska, Eliza Glodkowska-Mrowka
Chapter 6 - Next Generation Sequencing in Neurology and Psychiatry, Pages 97-136, Krystyna Szymańska, Krzysztof Szczałuba, Anna Kostera-Pruszczyk, Tomasz Wolańczyk
Chapter 7 - Next Generation Sequencing in Dysmorphology, Pages 137-151, Robert Smigiel, Urszula Demkow
Chapter 8 - Next Generation Sequencing in Vision and Hearing Impairment, Pages 153-170, Monika Ołdak
Chapter 9 - Next Generation Sequencing as a Tool for Noninvasive Prenatal Tests, Pages 171-188, Ozgur Cogulu
Chapter 10 - Clinical Applications for Next Generation Sequencing in Cardiology, Pages 189-215, Joanna Ponińska, Rafał Płoski, Zofia T. Bilińska
Chapter 11 - Next Generation Sequencing in Pharmacogenomics, Pages 217-240, Urszula Demkow
Chapter 12 - The Role of Next Generation Sequencing in Genetic Counseling, Pages 241-258, Asude Durmaz, Burak Durmaz
Chapter 13 - Next Generation Sequencing in Undiagnosed Diseases, Pages 259-269, Urszula Demkow
Chapter 14 - Organizational and Financing Challenges, Pages 271-279, Jacub Owoc
Chapter 15 - Future Directions, Pages 281-294, Michal Okoniewski, Rafał Płoski, Marek Wiewiorka, Urszula Demkow
Chapter 16 - Ethical and Psychosocial Issues in Whole-Genome Sequencing for Newborns, Pages 295-300, John D. Lantos
Chapter 17 - Next Generation Sequencing—Ethical and Social Issues, Pages 301-307, Andrzej Kochański, Urszula Demkow
Index, Pages 309-319

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