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Clinical application of a single compartment model to urea and creatinine kinetics in dialysis therapy

✍ Scribed by M.L. Sanfelippo; W.E. Walker; D.A. Hall; R.S. Swenson

Publisher: Elsevier Science
Year: 1978
Weight: 413 KB
Volume: 8
Category: Article
ISSN: 0010-468X
DOI: 10.1016/0010-468x(78)90058-2

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✦ Synopsis

A single compartment mathematical model has been shown to accurately describe changing serum concentrations of low molecular weight solutes (urea and creatinine) during dialysis. Clinical application of the model permits prediction of serum concentrations in response to changes in prescription of dialysis therapy. The programs presented here can be used to predict the effect of changes in treatment time and dialyzer clearance on serum concentrations. Sequential pre-and end-dialysis solute concentrations are displayed on a programmable pocket calculator. Dialyzer clearance during any individual dialysis can be calculated. These programs permit an evaluation of the efficacy of prescribed dialysis treatment schedules in advance of therapeutic trials.

Programmable calculator

Mathematical models Single compartment Dialysis Nephrology Uremia Solute kinetics

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Application of a programmable calculator

Application of a programmable calculator in data fitting according to one and two compartment open models in clinical pharmacokinetics

✍ S. Niazi 📂 Article 📅 1977 🏛 Elsevier Science ⚖ 189 KB

The plasma or blood concentration profiles are fitted by single or two compartment open models using log-linear regression analyses. For two compartment models, "feathering" is performed at 95% equilibration time obtained from raw pharmacokinetic data. The equations have been programmed onto a Texas