Clinical and Serologic Observations on 27 Patients with Felty's Syndrome

✍ Scribed by Mark Ruderman; Lawrence M. Miller; Robert S. Pinals

• Publisher: John Wiley and Sons
• Year: 1968
• Tongue: English
• Weight: 518 KB
• Volume: 11
• Category: Article
• ISSN: 0004-3591
• DOI: 10.1002/art.1780110302

✦ Synopsis

Felty' first described 5 cases of I arthritis, splenomegaly and leukopenia.

No further mention of this triad was made in the English literature until 1932, when Hanrahan and MillerZ reported another case of Felty's syndrome, the first in which splenectomy was performed. Although an occasional patient presenting with this triad may be found to have splenomegaly and leukopenia secondary to another process such as lymphoma or hepatic cirrho~is,~ the majority of cases do not have any disease other than rheumatoid arthriti~.~-lO Denko and Zumpft,l' as recently as 1962, reported 24 cases and concluded that the majority represented a chance association of arthritis, usually rheumatoid arthritis, and hypersplenism of various causes, most often systemic lupus erythematosus (SLE ). Their conclusions were based mainly on the pathologic findings in 15 spleens, 9 of which demonstrated "the fibrosis character-

From the Departments of Medicine, H U T V U