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Clinical and serologic study of sjögren's syndrome in patients with progressive systemic sclerosis

✍ Scribed by Thaddeus A. Osial JR.; Theresa L. Whiteside; Robert B. Buckingham; Gurmukh Singh; E. Leon Barnes; John M. Pierce; Gerald P. Rodnan

Publisher
John Wiley and Sons
Year
1983
Tongue
English
Weight
851 KB
Volume
26
Category
Article
ISSN
0004-3591

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✦ Synopsis

Fifty-eight patients with progressive systemic sclerosis (PSS) were evaluated clinically and by biopsy of the minor salivary glands of the lips for the presence of Sjogren's syndrome. Clinical findings included dry eyes in 38%' dry mouth in 32%' parotid enlargement in 4%' and an abnormal Schirmer's test in 34%. Histologic changes in lip biopsies included lymphocytic infiltrates characteristic of Sjiigren's syndrome in 17 individuals (29%). In 19 (33%) there was periglandular and intraglandular fibrosis (PSS-fibrosis) without significant inflammation, an alteration characteristic of PSS per se. In the remaining 22 patients (38%) with PSS, no

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