✦ LIBER ✦

Clinical and molecular aspects of retinoid therapy for acute promyelocytic leukemia

✍ Scribed by Raymond P. Warrell Jr.

Publisher: John Wiley and Sons
Year: 1997
Tongue: French
Weight: 35 KB
Volume: 70
Category: Article
ISSN: 0020-7136
DOI: 10.1002/(sici)1097-0215(19970207)70:4<496::aid-ijc25>3.0.co;2-c

No coin nor oath required. For personal study only.

✦ Synopsis

As a single agent, all-trans RA produces a higher rate of complete remission in APL than any other drug in any other neoplastic disease. The molecular findings in this illness have been exploited to develop a means of detecting and eradicating minimal residual disease. Compared with other forms of acute myeloid leukemia, this subtype is now associated with the highest proportion of patients in extended disease-free first remission who are presumably cured of their disease. APL is a prototype for understanding the pathogenesis of a malignant disease and the development of novel therapies that are targeted to specific molecular abnormalities.

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