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Clinical and microbiologic efficacy and safety profile of linezolid, a new oxazolidinone antibiotic

✍ Scribed by Giampaolo Corti; Roberta Cinelli; Franco Paradisi

Book ID
119563131
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
131 KB
Volume
16
Category
Article
ISSN
0924-8579

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Starting from the D-mannitol derivative (I), a straightforward synthesis of the chiral oxazolidines (VII) including precursors (VIIb) and (VIIc) of linezolid and eperezolid is detailed. Furthermore, the azide (VIIb) is converted to linezolid (IX) with thioacetic acid.