Clinical and laboratory associations of anticentromere antibody in patients with progressive systemic sclerosis
β Scribed by Virginia D. Steen; Gayle L. Ziegler; Dr. Gerald P. Rodnan; Thomas A. Medsger Jr.
- Publisher
- John Wiley and Sons
- Year
- 1984
- Tongue
- English
- Weight
- 612 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0004-3591
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To determine the clinical and immunogenetic features of systemic sclerosis (SSc) patients with anti-Th/To autoantibodies. Methods. HLA class I1 alleles were determined by DNA oligotyping in a large group of SSc patients with anticentromere antibodies (ACA), anti-topoisomerase I (anti-top0 I), and an
Fifty-eight patients with progressive systemic sclerosis (PSS) were evaluated clinically and by biopsy of the minor salivary glands of the lips for the presence of Sjogren's syndrome. Clinical findings included dry eyes in 38%' dry mouth in 32%' parotid enlargement in 4%' and an abnormal Schirmer's
## Abstract Fortyβone patients with progressive systemic sclerosis were studied for the presence of immune complexes by the fluidβ and solidβphase C1q binding, C1 activation, and the fluidβphase conglutinin assays. Complement activation and autoantibodies were also studied. Immune complexes were de