Clinical and immunological significance of antibodies to ro and La in systemic lupus erythematosus
โ Scribed by Morris Reichlin
- Publisher
- John Wiley and Sons
- Year
- 1982
- Tongue
- English
- Weight
- 536 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0004-3591
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๐ SIMILAR VOLUMES
Sera from patients with SLE frequently contain IgM and IgG antibodies with multiple specificities for lymphocyte surface determinants, including autologous antigens. The IgM antibodies are of relatively low binding avidity and exhibit broad reactivity with B and T lymphocytes from most individuals.
## Abstract To further clarify the clinical significance of nDNA antibodies in systemic lupus erythematosus, 70 patients were studied longitudinally over an average period of 3 years each. Serum hemolytic complement (CH50) and nDNA antibodies measured by antigen binding and complement fixation were
## Objective: To determine whether antiphospholipid antibodies (apl) occur before the diagnosis of systemic lupus erythematosus (sle) and before initial clotting events, and whether their presence early in the disease course influences clinical outcome. ## Methods: Serum samples obtained from 130
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