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Clinical and genetic characteristics of Mexican Huntington's disease patients

✍ Scribed by María Elisa Alonso; Adriana Ochoa; Marie-Catherine Boll; Ana Luisa Sosa; Petra Yescas; Marisol López; Rosario Macias; Itziar Familiar; Astrid Rasmussen

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
348 KB
Volume
24
Category
Article
ISSN
0885-3185

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✦ Synopsis

Abstract

We report the characteristics of 691 Mexican patients with Huntington's disease (HD). These patients, representing 401 families, constitute the largest series of Mexican HD cases as yet described in the literature. We found the clinical characteristics of these patients to be similar to those of other populations, but we observed a higher frequency of infantile cases, a shorter disease duration and a lower suicide rate. In 626 cases, for which molecular analyses were available, CAG‐trinucleotide expansion size ranged from 37–106 repeats. The large number of CAG repeats (19.04 ± 3.02) in normal alleles and the presence of new mutations suggest that the overall prevalence of HD in the Mexican population could be expected to be within range of, or higher than, that reported for Europeans. © 2009 Movement Disorder Society

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