✦ LIBER ✦

“Click” Synthesis of Fatty Acid Derivatives as Fast-Degrading Polyanhydride Precursors

✍ Scribed by Cristina Lluch; Gerard Lligadas; Joan C. Ronda; Marina Galià; Virginia Cadiz

Publisher: John Wiley and Sons
Year: 2011
Tongue: English
Weight: 464 KB
Volume: 32
Category: Article
ISSN: 1022-1336
DOI: 10.1002/marc.201100155

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Fast‐degrading linear and branched polyanhydrides are obtained by melt‐condensation of novel di‐ and tri‐carboxylic acid monomers based on oleic and undecylenic acid synthesized using photoinitiated thiol‐ene click chemistry. ^1^H NMR spectroscopy, size exclusion chromatography, differential scanning calorimetry, thermogravimetric analysis, and FT‐IR spectroscopy have been used to fully characterize these polymers. The hydrolytic degradation of these polymers was studied by means of weight loss, anhydride bond loss, and changes in molecular weight, showing fast degrading properties. Drug release studies from the synthesized polyanhydrides have also been conducted, using rhodamine B as a hydrophobic model drug, to evaluate the potential of these polymers in biomedical applications. magnified image

📜 SIMILAR VOLUMES

Cycloserine Fatty Acid Derivatives (VI)

Cycloserine Fatty Acid Derivatives (VI) as Prodrugs: Synthesis, Degradation and in vitro Skin Permeability.

✍ Thorsteinn Thorsteinsson; Mar Masson; Tomi Jarvinen; Tapio Nevalainen; Thorstein 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 27 KB

ChemInform Abstract: Renewable Materials

ChemInform Abstract: Renewable Materials as Precursors of Linear Nitrile Acid Derivatives via Cross-Metathesis of Fatty Esters and Acids with Acrylonitrile and Fumaronitrile.

✍ Raluca Malacea; Cedric Fischmeister; Christian Bruneau; Jean-Luc Dubois; Jean-Lu 📂 Article 📅 2009 🏛 John Wiley and Sons ⚖ 27 KB 👁 2 views

ChemInform Abstract: Synthesis of Hydrop

ChemInform Abstract: Synthesis of Hydroperoxide and Perketal Derivatives of Polyunsaturated Fatty Acids as Potential Antimalarial Agents.

✍ M. J. PITT; C. J. EASTON; T. A. ROBERTSON; L. M. KUMARATILAKE; A. FERRANTE; A. P 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 32 KB 👁 1 views

ChemInform Abstract: Synthesis of Branch

ChemInform Abstract: Synthesis of Branched Chain 2-Deoxyoct-3-ulosonic Acid Derivatives as Precursors for C-Nucleoside Analogues.

✍ R. MEISEL; K. PESEKE; H. REINKE 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 37 KB 👁 2 views

ChemInform Abstract: Synthesis of Optica

ChemInform Abstract: Synthesis of Optically Active 4-Hydroxypyrazolidin-3-ones as Precursors for β-Amino-α-hydroxycarboxylic Acid Derivatives.

✍ K. WOYDOWSKI; J. LIEBSCHER 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 36 KB 👁 1 views

Synthesis of Chiral Tetramic Acids Using

Synthesis of Chiral Tetramic Acids Using Activated Derivatives of N- Protected α-Amino Acids as Precursors: Structural Characterization of Tetramic aci-Complexes with Metal Ions

✍ J. Markopoulos; A. Detsi; E. Gavrielatos; G. Athanasellis; O. Igglessi-Markopoul 📂 Article 📅 2005 🏛 John Wiley and Sons ⚖ 9 KB 👁 1 views