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‘Click peptide’: a novel ‘O-acyl isopeptide method’ for peptide synthesis and chemical biology-oriented synthesis of amyloid β peptide analogues

✍ Scribed by Youhei Sohma; Atsuhiko Taniguchi; Taku Yoshiya; Yousuke Chiyomori; Fukue Fukao; Setsuko Nakamura; Mariusz Skwarczynski; Takuma Okada; Keisuke Ikeda; Yoshio Hayashi; Tooru Kimura; Shun Hirota; Katsumi Matsuzaki; Yoshiaki Kiso

Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
237 KB
Volume
12
Category
Article
ISSN
1075-2617

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✦ Synopsis

Abstract

After over a decade of studies on aspartic protease inhibitors and water‐soluble prodrugs, we have been developing a novel method, since 2003, called ‘O‐acyl isopeptide method’, for the synthesis of peptides containing difficult sequences. With our recent discoveries of ‘O‐acyl isodipeptide unit’ and the ‘racemization‐free segment condensation method’, this method has further evolved as a general synthetic method for peptides. Moreover, ‘Click Peptide’, which could be a powerful tool for identifying the pathological functions of amyloid β peptides in Alzheimer's disease, represents a valuable use of the isopeptide method in Chemical Biology‐oriented research. Copyright © 2006 European Peptide Society and John Wiley & Sons, Ltd.

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✍ Youhei Sohma; Yoshiaki Kiso 📂 Article 📅 2006 🏛 John Wiley and Sons ⚖ 9 KB 👁 2 views

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‘O-Acyl isopeptide method’ for peptide s
‘O-Acyl isopeptide method’ for peptide synthesis: Solvent effects in the synthesis of Aβ1–42 isopeptide using ‘O-acyl isodipeptide unit’
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## Abstract ‘__O__‐Acyl isopeptide method’ is an efficient synthetic method for peptides. We designed ‘__O__‐acyl isodipeptide units’, Boc‐Ser/Thr(Fmoc‐Xaa)‐OH, as important building blocks to enable routine use of the __O__‐acyl isopeptide method. In the synthesis of an Aβ1–42 isopeptide using __O