Click Chemistry to Construct Fluorescent Oligonucleotides for DNA Sequencing
โ Scribed by Seo, Tae Seok; Li, Zengmin; Ruparel, Hameer; Ju, Jingyue
- Book ID
- 119993185
- Publisher
- American Chemical Society
- Year
- 2003
- Tongue
- English
- Weight
- 101 KB
- Volume
- 68
- Category
- Article
- ISSN
- 0022-3263
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๐ SIMILAR VOLUMES
A group of fluorophore-labeled peptide substrates of Src kinases have been synthesized with the aid of click chemistry. Some of the generated peptides exhibit an increase in fluorescence upon phosphorylation and are capable of detecting Src kinases with high sensitivity and specificity. Their availa
Different thymidine derivatives bearing either an iodoaryl moiety at the 5 0 position or a dialkylsilyl group at the 3 0 position have been efficiently synthesized as precursors for carbon-11 or fluorine-18 labeling, respectively. Furthermore, iodoarylated thymidine derivatives have been incorporate
## Abstract The synthesis of 4(5)โ(bromomethyl)fluorescein, which can be used as its 3โฒ,6โฒโdibenzoyl derivative 7 for the labelling of nucleosides is described. Pyrimidine nucleosides such as 3โฒโand/or5โฒโprotected 2โฒโdeoxyuridine and thymidine are labelled by 7 at N^3^ of the heterocyclic base. The