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A ‘click chemistry’ approach to the efficient synthesis of modified nucleosides and oligonucleotides for PET imaging

✍ Scribed by Damien James; Jean-Marc Escudier; Eric Amigues; Jürgen Schulz; Christiane Vitry; Thomas Bordenave; Magali Szlosek-Pinaud; Eric Fouquet

Publisher: Elsevier Science
Year: 2010
Tongue: French
Weight: 359 KB
Volume: 51
Category: Article
ISSN: 0040-4039
DOI: 10.1016/j.tetlet.2009.12.120

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✦ Synopsis

Different thymidine derivatives bearing either an iodoaryl moiety at the 5 0 position or a dialkylsilyl group at the 3 0 position have been efficiently synthesized as precursors for carbon-11 or fluorine-18 labeling, respectively. Furthermore, iodoarylated thymidine derivatives have been incorporated into oligonucleotides giving an original way to label them with carbon-11.

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