Click Chemistry as a Macrocyclization Tool in the Solid-Phase Synthesis of Small Cyclic Peptides
β Scribed by Turner, Rushia A.; Oliver, Allen G.; Lokey, R. Scott
- Book ID
- 120040782
- Publisher
- American Chemical Society
- Year
- 2007
- Tongue
- English
- Weight
- 273 KB
- Volume
- 9
- Category
- Article
- ISSN
- 1523-7060
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π SIMILAR VOLUMES
The anchoring the first amino acid in Boc chemistry to a 4-(3-hydroxy-4methylpentyl)phenylacetic acid linker is described and compared to the conventional Pam resin. The peptidyl-4-(4-methyl-3-pentoxy)phenylacetamide linkage is slightly more stable to TFA than the Pam linker but in contrast to the P
We have previously described the conditions by which peptide synthesis by the solid-phase fragment condensation approach can be carried out using crown ethers as non-covalent protection for the N alpha-amino group. Here we demonstrate that the procedure can be extended to large, partially protected