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Cleavage of the N-PChd group from protected amino acids and peptides by cathodic reduction

✍ Scribed by M.Hassen Khalifa; Anton Rieker


Publisher
Elsevier Science
Year
1984
Tongue
French
Weight
236 KB
Volume
25
Category
Article
ISSN
0040-4039

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✦ Synopsis


Amino acid and peptide esters protected by the PChd group can be deprotected cathodically under mild conditions.

We have recently introduced the di--butylated 1-phenyl-4-oxo-2,5-


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## Abstract __N__‐protected peptides, which are important intermediates as a carboxyl component in the fragment condensation method, have been prepared in high yields by the reaction of __o__‐nitrophenylsulfenyl (Nps) __N__‐carboxy α‐amino acid anhydrides with unprotected peptides and amino acids i