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Cleavage of Osteopontin by Matrix Metalloproteinase-12 Modulates Experimental Autoimmune Encephalomyelitis Disease in C57BL/6 Mice

✍ Scribed by Angelika Goncalves DaSilva; Lucy Liaw; V. Wee Yong

Book ID: 117971154
Publisher: American Society for Investigative Pathology
Year: 2010
Tongue: English
Weight: 790 KB
Volume: 177
Category: Article
ISSN: 0002-9440
DOI: 10.2353/ajpath.2010.091081

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## Abstract Multiple sclerosis (MS) is an autoimmune, demyelinating disease of the central nervous system (CNS). Like MS, the animal model experimental autoimmune encephalomyelitis (EAE) is characterized by CNS inflammation and demyelination and can follow a relapsing–remitting (RR) or chronic (CH)