Cleavage of Hepatitis C Virus Nonstructural Protein 5A by a Caspase-like Protease(s) in Mammalian Cells
β Scribed by Shinya Satoh; Masami Hirota; Tohru Noguchi; Makoto Hijikata; Hiroshi Handa; Kunitada Shimotohno
- Book ID
- 112272956
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- English
- Weight
- 348 KB
- Volume
- 270
- Category
- Article
- ISSN
- 0042-6822
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The following corrections have since been made: ''BMS-790052'' has been replaced throughout with ''daclatasvir''; ''BMS-50032'' has been replaced throughout with ''asunaprevir''. The article has been updated online and in print.
The hepatitis C virus (HCV) nonstructural 5A (NS5A) protein has been implicated in the inherent resistance of HCV to interferon (IFN) antiviral therapy in clinical studies. Biochemical studies have demonstrated that NS5A interacts in vitro with and inhibits the IFN-induced, RNAdependent protein kina