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Cleavage of Hepatitis C Virus Nonstructural Protein 5A by a Caspase-like Protease(s) in Mammalian Cells

✍ Scribed by Shinya Satoh; Masami Hirota; Tohru Noguchi; Makoto Hijikata; Hiroshi Handa; Kunitada Shimotohno


Book ID
112272956
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
348 KB
Volume
270
Category
Article
ISSN
0042-6822

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The hepatitis C virus (HCV) nonstructural 5A (NS5A) protein has been implicated in the inherent resistance of HCV to interferon (IFN) antiviral therapy in clinical studies. Biochemical studies have demonstrated that NS5A interacts in vitro with and inhibits the IFN-induced, RNAdependent protein kina