𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Nonstructural protein 5A does not contribute to the resistance of hepatitis C virus replication to interferon alpha in cell culture

✍ Scribed by Marc aus dem Siepen; Volker Lohmann; Manfred Wiese; Stefan Ross; Michael Roggendorf; Sergei Viazov


Book ID
113946340
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
367 KB
Volume
336
Category
Article
ISSN
0042-6822

No coin nor oath required. For personal study only.


πŸ“œ SIMILAR VOLUMES


Characterization of the effects of hepat
✍ Stephen J. Polyak; Denise M. Paschal; Susan McArdle; Michael J. Jr.; Darius Mora πŸ“‚ Article πŸ“… 1999 πŸ› John Wiley and Sons 🌐 English βš– 338 KB πŸ‘ 1 views

The hepatitis C virus (HCV) nonstructural 5A (NS5A) protein has been implicated in the inherent resistance of HCV to interferon (IFN) antiviral therapy in clinical studies. Biochemical studies have demonstrated that NS5A interacts in vitro with and inhibits the IFN-induced, RNAdependent protein kina

Mutations in the nonstructural 5A gene o
✍ S Zeuzem; J H Lee; W K Roth πŸ“‚ Article πŸ“… 1997 πŸ› John Wiley and Sons 🌐 English βš– 179 KB πŸ‘ 2 views

The response rate to interferon alfa (IFN-alpha) in patients infected with hepatitis C virus (HCV) genotype 1 isolates is poor. A region associated with sensitivity to IFN has been identified in subtype HCV-1b isolates from Japanese patients in the carboxyterminal half of the nonstructural protein N

Mutations in the nonstructural region 5B
✍ Kazumasa Watanabe; Kentaro Yoshioka; Motoyoshi Yano; Masatoshi Ishigami; Koji Uk πŸ“‚ Article πŸ“… 2005 πŸ› John Wiley and Sons 🌐 English βš– 174 KB πŸ‘ 2 views

## Abstract The nonstructural 5B (NS5B) protein of hepatitis C virus possesses RNA‐dependent RNA polymerase activity and plays an essential role in viral replication. The mutations in NS5B were determined and the correlation with viral load and response to interferon (IFN) were assessed. The entire

Mutations in the nonstructural protein 5
✍ Komatsu, Haruki; Fujisawa, Tomoo; Inui, Ayano; Miyagawa, Yoshihiro; Onoue, Masah πŸ“‚ Article πŸ“… 1997 πŸ› John Wiley and Sons 🌐 English βš– 38 KB πŸ‘ 3 views

A region associated with sensitivity to interferon (IFN) has been identified previously in the nonstructural protein 5A (NS5A) of hepatitis C virus (HCV) genotype 1b. A study was undertaken to determine whether the presence of mutations in the NS5A 2209-2248 sequence could serve as a predictor of re

Genotypic and phenotypic analysis of var
✍ Robert A. Fridell; Chunfu Wang; Jin-Hua Sun; Donald R. O'Boyle II; Peter Nower; πŸ“‚ Article πŸ“… 2011 πŸ› John Wiley and Sons 🌐 English βš– 338 KB πŸ‘ 1 views

The NS5A replication complex inhibitor, BMS-790052, inhibits hepatitis C virus (HCV) replication with picomolar potency in preclinical assays. This potency translated in vivo to a substantial antiviral effect in a single-ascending dose study and a 14-day multiple-ascending dose (MAD) monotherapy stu