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Clastic binding on the opiate receptor

โœ Scribed by Belleau, B.; Morgan, P.

Book ID
126115865
Publisher
American Chemical Society
Year
1974
Tongue
English
Weight
302 KB
Volume
17
Category
Article
ISSN
0022-2623

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A clastic binding hypothesis for opiate-receptor interactions, in which the key step in eliciting the opiate response is an electron transfer from the opiate nitrogen to the receptor, is analyzed from a chemical point of view and is found to be chemically feasible. An extended form of this hypothesi

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Ab initio (4-31G) molecular orbital calculations were performed on model systems to investigate the proton-transfer version of the clastic binding hypothesis for opiate-receptor interactions. Ammonia was chosen as the model for the nitrogen-containing portion of the opiate molecule, while ammonia an