✦ LIBER ✦

New insights in the clastic binding hypothesis for opiate—receptor interactions I: Electron-transfer mechanism

✍ Scribed by Vera M. Kolb

Book ID: 102916196
Publisher: John Wiley and Sons
Year: 1984
Tongue: English
Weight: 607 KB
Volume: 73
Category: Article
ISSN: 0022-3549
DOI: 10.1002/jps.2600730603

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✦ Synopsis

A clastic binding hypothesis for opiate-receptor interactions, in which the key step in eliciting the opiate response is an electron transfer from the opiate nitrogen to the receptor, is analyzed from a chemical point of view and is found to be chemically feasible. An extended form of this hypothesis is proposed in order to accommodate recent observations about the N-demethylation of morphines in the brain. An in vitro model system for studying the electron-transfer reactions of morphines is proposed, and the initial experiments in this system are reported.

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New insights in the clastic binding hypothesis for opiate—receptor interactions II: Proton-transfer mechanism

✍ Vera M. Kolb; Steve Scheiner 📂 Article 📅 1984 🏛 John Wiley and Sons 🌐 English ⚖ 586 KB

Ab initio (4-31G) molecular orbital calculations were performed on model systems to investigate the proton-transfer version of the clastic binding hypothesis for opiate-receptor interactions. Ammonia was chosen as the model for the nitrogen-containing portion of the opiate molecule, while ammonia an