Classification ofα 2-HS-glycoprotein (α 2HS) types by isoelectric focusing
✍ Scribed by Umetsu, K. ;Kashimura, S. ;Ikeda, N. ;Suzuki, T.
- Publisher
- Springer-Verlag
- Year
- 1983
- Tongue
- English
- Weight
- 239 KB
- Volume
- 91
- Category
- Article
- ISSN
- 1437-1596
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The genetically determined polymorphism of alpha 2 HS-glycoprotein was analyzed by immunoblotting ultrathin-layer polyacrylamide gel isoelectric focusing in the pH range 4-6.5 and neuraminidase pretreated sera. In a Libyan population sample from Tripoli (n = 110) three common phenotypes, alpha 2 HSG
a2HS glycoprotein is a normal constituent of plasma. It has a high affinity for hydroxyapatite and is concentrated in bone 100-fold greater than albumin, however its biological function in bone is not known. We have purified a2HS from human plasma and examined it for evidence of chemotactic activity