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Classification of transferrin (Tf) subtypes by isoelectric focusing

✍ Scribed by Weidinger, S. ;Schwarzfischer, F. ;Cleve, H.

Book ID: 104661007
Publisher: Springer-Verlag
Year: 1980
Tongue: English
Weight: 598 KB
Volume: 85
Category: Article
ISSN: 1437-1596
DOI: 10.1007/bf00201287

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✦ Synopsis

A sample of 450 sera from unrelated individuals from Southern Germany was examined by isoelectric focusing on polyacrylamide gels. Three common subtypes, TfC1, C2-1, and C2, were differentiated. In addition, the rare variants TfB1, B1-2, B2, D1, D1-2, D2, and D3 were observed. The frequencies of the Tf alleles in our sample were found to be: Tf c~= 0.8544, Tf c2 = 0,1367, Tf m = 0.0011, Tf m-2 = 0.0022, Tf B2 = 0.0045, and Tf TM = 0.0011. Analysis of 73 parents with 73 children did not show deviations from the expected mode of inheritance. Modification of the method by addition of 0.01 M FeC13 to the sera prior to examination did, however, reveal further variation and permitted the distinction of six subtypes, C1, C2-1, C2, C3, C3-1, and C3-2.

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