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Classification of Acid Denaturation of Proteins: Intermediates and Unfolded States

✍ Scribed by Fink, Anthony L.; Calciano, Linda J.; Goto, Yuji; Kurotsu, Takuzo; Palleros, Daniel R.

Book ID
125463413
Publisher
American Chemical Society
Year
1994
Tongue
English
Weight
968 KB
Volume
33
Category
Article
ISSN
0006-2960

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It has been shown that human stefin B exhibits molten globule intermediates when denatured by acid or GuHCl. In the presence of TFE, it transforms into a highly helical state. In our first study on its folding mechanism (Z Λ‡erovnik et al., Proteins 32:296-303), the kinetics measured by circular dich