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Class I T-cell epitope prediction: Improvements using a combination of proteasome cleavage, TAP affinity, and MHC binding

✍ Scribed by Irini A. Doytchinova; Darren R. Flower


Book ID
116755793
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
270 KB
Volume
43
Category
Article
ISSN
0161-5890

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Reverse immunogenetic approaches attempt to optimize the selection of candidate epitopes, and thus minimize the experimental effort needed to identify new epitopes. When predicting cytotoxic T cell epitopes, the main focus has been on the highly specific MHC class I binding event. Methods have also