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Class I phosphoinositide 3-kinases

✍ Scribed by Karen E. Anderson; Shaun P. Jackson

Book ID
117755961
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
235 KB
Volume
35
Category
Article
ISSN
1357-2725

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Many signaling pathways converge on and regulate phosphoinositide 3-kinase (PI3K) enzymes whose inositol lipid products are key mediators of intracellular signaling. Different PI3K isoforms generate specific lipids that bind to FYVE and pleckstrin homology (PH) domains in a variety of proteins, affe