✦ LIBER ✦

Cisplatinum and interstitial laser therapy for advanced head and neck cancer: A preclinical study

✍ Scribed by Paiva, Marcos B.; Saxton, Romaine E.; VanderWerf, Quinten M.; Bell, Theodore; Eshraghi, Adrien A.; Graeber, Ines P.; Feyh, Jens; Castro, Dan J.

Publisher: John Wiley and Sons
Year: 1997
Tongue: English
Weight: 202 KB
Volume: 21
Category: Article
ISSN: 0196-8092
DOI: 10.1002/(sici)1096-9101(1997)21:5<423::aid-lsm3>3.0.co;2-s

No coin nor oath required. For personal study only.

✦ Synopsis

Background and Objective

: Direct intratumor injection of cisplatinum (CDDP) and laser therapy were tested for improved treatment of squamous cell carcinoma (SCCA). Study Design/Materials and Methods: Human SCCA tumors were grown as sc transplants in nude mice and injected with CDDP (0.4-1.2 mg/gm) in water or in collagen-based gel carrier with epinephrine (epi-gel), followed by interstitial laser therapy (ILT) via 0.6 mm fiberoptics (532 nm/300J). Results: Tumors injected with CDDP epi-gel exhibited a partial response with 2-4-fold tumor growth delay, compared to aqueous drug or untreated SCCA transplants during 10-week followup. Combined drug and laser therapy significantly decreased tumor volume with recurrence in only 25% (2/8) of animals tested, compared to 66% tumor regrowth (10/15) after ILT alone. Conclusion: These initial results suggest laser chemotherapy may become an effective treatment for advanced head and neck cancer.

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