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Cisplatin-Induced Hepatotoxicity Is Enhanced by Elevated Expression of Cytochrome P450 2E1

โœ Scribed by Lu, Y.


Book ID
121344527
Publisher
Oxford University Press
Year
2005
Tongue
English
Weight
915 KB
Volume
89
Category
Article
ISSN
1096-6080

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Cytochrome P450 2E1 (CYP2E1) may be a central pathway in generating oxidative stress, reactive oxygen species, and causing hepatotoxic injury by alcohol and various hepatotoxins. This study evaluated the ability of CYP2E1 to potentiate or synergize the hepatotoxicity of Fas in vivo. C57BL/6 mice wer