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Cisplatin, an antineoplastic reagent, inhibits histamine release and synthesis in rat basophilic leukemia cells (RBL-2H3)

โœ Scribed by M. Takarada; H. Hamakawa; Y. Goto; K. Maeyama; H. Tanioka


Book ID
117612248
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
64 KB
Volume
26
Category
Article
ISSN
0901-5027

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โœ Kazutaka Maeyama; Masayuki Sasaki; Takehiko Watanabe ๐Ÿ“‚ Article ๐Ÿ“… 1991 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 874 KB

In rat basophilic leukemia cells (RBL-2H3), a tumor analogue of mast cells, the aggregation of IgE receptors initiates increase in the intracellular concentration of calcium ([Ca2+]i), monitored with the fluorescent Ca probe fura-2, and finally results in histamine secretion. In cell suspensions, ho