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Cis-platinum and 5-fluorouracil as induction therapy for advanced head and neck cancer

✍ Scribed by Arthur Weaver; Susan Flemming; Julie Kish; Henry Vandenberg; John Jacob; John Crissman; Muhyi Al-Sarraf

Book ID
115693490
Publisher
Elsevier Science
Year
1982
Tongue
English
Weight
448 KB
Volume
144
Category
Article
ISSN
0002-9610

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## Abstract A total of 44 patients with previously untreated Stage IV squamous cell carcinomas of the head and neck were treated with a combination of cis‐platinum (100 mg/sq m) and 96‐hour infusion of 5‐fluorouracil (5‐FU) (1,000 mg/sq m/day) in two courses or with cis‐platinum (100 mg/sq m) and 1

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Fifty-four previously untreated patients with locally advanced resectable squamous cell carcinoma of the head and neck (SCCHN) were enrolled into a prospective randomized controlled trial to evaluate whether induction chemotherapy improves the disease-free survival compared to the standard treatment