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Circumvention of glucocorticoid resistance in childhood leukemia

โœ Scribed by E.G. Haarman; G.J.L. Kaspers; R. Pieters; M.M.A. Rottier; A.J.P. Veerman

Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
209 KB
Volume
32
Category
Article
ISSN
0145-2126

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Glucocorticoid therapy forms a crucial first-line treatment for childhood acute lymphoblastic leukemia (ALL). However, glucocorticoid resistance is a therapeutic problem with an unclear molecular mechanism. 11beta-Hydroxysteroid dehydrogenase-1 (11beta-HSD1) is expressed in glucocorticoid target tis