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Circulating immune complexes in untreated psoriasis

✍ Scribed by L. Lindholm; H. Mobacken; B. -L. Magnusson


Publisher
Springer-Verlag
Year
1987
Tongue
English
Weight
344 KB
Volume
279
Category
Article
ISSN
0340-3696

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✦ Synopsis


Three different in vitro assays for the demonstration of circulating immune complexes were compared in 49 patients with psoriasis. Grannlocytes from psoriatic subjects contained immune complex-like material in 25 patients (51%). When psoriatic serum was incubated with granulocytes from healthy blood donors, phagocytosed material was found in 18 patients (37%). The Raji-ceH assay was only positive in two of 27 subjects (7%). Of the patients 71% tested positively with one of the granulocyte phagocytosis tests. Both tests were positive simultaneously in 16% and negative in 29% of the patients. The pathogenetic significance of the immune complex-like material is unclear.


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