Circulating immune complexes in untreated psoriasis
β Scribed by L. Lindholm; H. Mobacken; B. -L. Magnusson
- Publisher
- Springer-Verlag
- Year
- 1987
- Tongue
- English
- Weight
- 344 KB
- Volume
- 279
- Category
- Article
- ISSN
- 0340-3696
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β¦ Synopsis
Three different in vitro assays for the demonstration of circulating immune complexes were compared in 49 patients with psoriasis. Grannlocytes from psoriatic subjects contained immune complex-like material in 25 patients (51%). When psoriatic serum was incubated with granulocytes from healthy blood donors, phagocytosed material was found in 18 patients (37%). The Raji-ceH assay was only positive in two of 27 subjects (7%). Of the patients 71% tested positively with one of the granulocyte phagocytosis tests. Both tests were positive simultaneously in 16% and negative in 29% of the patients. The pathogenetic significance of the immune complex-like material is unclear.
π SIMILAR VOLUMES
Serum circulating immune complexes were quantitated by means of a Cl q-binding enzyme-linked immunosorbent assay in the serum from 46 untreated bronchogenic carcinoma patients, and the results compared with those obtained in 48 patients with nonmalignant thoracic diseases and 75 normal healthy donor
## Abstract Serum immune complexes were measured in 22 patients with eosinophilic fasciitis, 8 of whom had serial determinations. Elevated levels were found by Raji cell radioimmunoassay in 14 (64%) patients, by agarose gel electrophoresis in 13 (59%), and by C1q agglutinationβinhibition in 9 (41%)