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Circular dichroism of the “random” polypeptide chain

✍ Scribed by M. Lois Tiffany; S. Krimm

Publisher
Wiley (John Wiley & Sons)
Year
1969
Tongue
English
Weight
674 KB
Volume
8
Category
Article
ISSN
0006-3525

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✦ Synopsis

The circular dichroism (CD) spectrum of an unordered polypeptide chain does not correspond, as has been assumed heretofore, to that of a charged chain such as poly-~glutamic acid or poly-clysine. The latter have been shown to have locally ordered structures with characteristic CD spectra. We have now obtained CD spectra of the unordered forms of the above synthetic polypeptides, as well as of two fibrous proteins (collagen and feather keratin) and a globular protein (myoglobin). These spectra are all similar to that of unordered polyproline, having a negative band in the vicinity of 200 ma and no additional bands at longer wavelengths. The lack of structural uniqueness of the unordered polypeptide chain is emphasized by these studies.

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