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Vibrational circular dichroism of polypeptides. VI. polytyrosine α-helical and random-coil results

✍ Scribed by S. C. Yasui; T. A. Keiderling

Publisher
Wiley (John Wiley & Sons)
Year
1986
Tongue
English
Weight
559 KB
Volume
25
Category
Article
ISSN
0006-3525

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✦ Synopsis

We have measured the VCD of polytyrosine in the amide I and I1 regions in dimethyl sulfoxide (DMSO) and in 8020 mixtures of DMSO with trifluoroethanol, trifluoroacetic acid (TFA), and dichloroacetic acid and in 50:50 mixtures of DMSO and trimethyl phosphate (TMP). Additionally, VCD was obtained for deuterated polytyrosine in DMSO and DMSOD,O, DMSOTFA(dl), and DMSOTMP mixtures as before. Amide A VCD was obtained in DMSO and DMS0:TMP mixtures. In the pure solvent, VCD of an opposite sign was seen as compared with that seen in the mixtures. The latter were characteristic in sign pattern and shape of right-handed a-helices for poly(L-tyrosine). The pure po1ytyrosine:DMSO results are similar to those of polylysine:D,O a t neutral pH and poly(P-benzyl-aspartate) in DMSO and may be characteristic of random-coil VCD.

📜 SIMILAR VOLUMES

Vibrational circular dichroism of polype
Vibrational circular dichroism of polypeptides. III. Film studies of several α-helical and β-sheet polypeptides
✍ A. C. Sen; T. A. Keiderling 📂 Article 📅 1984 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 630 KB

## Abstract Vibrational CD (VCD) of amides A, I, and II vibrations of a variety of polypeptide films have been measured. VCD of films of α‐helical and β‐sheet structures are compared in the three regions. Reproducible spectra could only be obtained for thin films free of orientation dependence. The

Vibrational circular dichroism of polype
Vibrational circular dichroism of polypeptides. II. Solution amide II and deuteration results
✍ A. C. Sen; T. A. Keiderling 📂 Article 📅 1984 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 708 KB

## Synopsis Vibrational CD (VCD) of amide I and I1 vibrations of several a-helical polypeptides have been measured in solution. For the amide I1 as well as the amide I [previously published: Lal, B.B. & Nafie, L.A. (1982) Biopolymers 21, 21611 we find the VCD to be characteristic of the polypeptid