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Circadian pharmacokinetics and converting enzyme inhibition of enalapril maleate in healthy volunteers

✍ Scribed by K. Weisser; J. Schloos; R. Düsing; H. Vetter; E. Mutschler


Book ID
115885775
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
228 KB
Volume
183
Category
Article
ISSN
0014-2999

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Possible circadian changes in the pharmacokinetics and effect on serum angiotensin-converting enzyme (ACE) activity of the ACE inhibitor enalapril have been studied in 8 healthy subjects after oral ingestion of 10 mg enalapril maleate either at 08.00 h or 20.00 h. The time to peak serum concentratio

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Enalapril, the ethyl ester of a potent angiotensin converting enzyme inhibitor, enalaprilat, was administered to healthy volunteers as a capsule containing 10 mg of the maleate salt, every 24h for eight doses. Serum profiles show little accumulation of enalaprilat following eight daily doses of enal