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Circadian modifications of blood brain barrier (BBB) permeability in the rat

✍ Scribed by A. Saija; P. Princi; R. DePasquale; G. Costa


Book ID
114075355
Publisher
Elsevier Science
Year
1988
Weight
110 KB
Volume
20
Category
Article
ISSN
0031-6989

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Permeability data from MDR1-MDCKII and PAMPA-BBB assays were compared to data from in situ brain perfusion to evaluate the accuracy of in vitro assays in predicting in vivo blood-brain barrier (BBB) permeability. PAMPA-BBB significantly correlated to in situ brain perfusion, however, MDR1-MDCKII had