Circadian haematotoxicity of the antiepileptic valproic acid in mice
โ Scribed by Ben-Cherif, Wafa; Dridi, Ichrak; Hassine, Mohsen; Ben-Attia, Mossadok; Aouam, Karim; Reinberg, Alain; Boughattas, Naceur
- Book ID
- 123103117
- Publisher
- Versita
- Year
- 2014
- Tongue
- English
- Weight
- 870 KB
- Volume
- 12
- Category
- Article
- ISSN
- 1214-021X
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
## Abstract **BACKGROUND:** Although valproic acid (VPA) is used extensively for treating various kinds of epilepsy, it causes hepatotoxicity and teratogenicity. In an attempt to develop a more potent and safer second generation to VPA drug, the amide derivatives of the tetramethylcyclopropyl VPA a
The antiepileptic drug valproic acid (VPA) and teratogenic VPA analogues have been demonstrated to inhibit cell motility and affect cell morphology. We here show that disruption of microtubules or of microfilaments by exposure to nocodazole or cytochalasin D had different effects on morphology of co