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Chronotolerance study of the antiepileptic drug valproic acid in mice

โœ Scribed by Wafa Ben-Cherif, Ichrak Dridi, Karim Aouam, Mossadok Ben-Attia, Alain Reinberg, Naceur A Boughattas


Book ID
119907116
Publisher
BioMed Central
Year
2012
Tongue
English
Weight
245 KB
Volume
10
Category
Article
ISSN
1740-3391

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## Abstract **BACKGROUND:** Although valproic acid (VPA) is used extensively for treating various kinds of epilepsy, it causes hepatotoxicity and teratogenicity. In an attempt to develop a more potent and safer second generation to VPA drug, the amide derivatives of the tetramethylcyclopropyl VPA a