Circadian rhythm and seasonal dependence
โ
M. C. Mormont; R. Roemeling; R. B. Sothern; J. S. Berestka; T. R. Langevin; M. W
๐
Article
๐
1988
๐
Springer US
๐
English
โ 860 KB
Compared to doxorubicin, equimolar epirubicin toxicity is reduced by about 50~ by the epimerization of a hydrogen and hydroxyl group at the 4' position of the anthracycline sugar moeity. The circadian timing of doxorubicin administration markedly affects its lethal and sub-lethal bone marrow and gut