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Cip1 blocks the initiation of DNA replication in Xenopus extracts by inhibition of cyclin-dependent kinases

โœ Scribed by Ulrich P. Strausfeld; Mike Howell; Rachel Rempel; James L. Maller; Tim Hunt; J.Julian Blow


Book ID
114317392
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
940 KB
Volume
4
Category
Article
ISSN
0960-9822

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Xenopus egg extracts initiate replication at specific origin sites within mammalian G1-phase nuclei. Similarly, S-phase extracts from Saccharomyces cerevisiae initiate DNA replication within yeast nuclei at specific yeast origin sequences. Here we show that Xenopus egg extracts can initiate DNA repl