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Cigarette smoking is strongly associated with mutation of the K-ras gene in primary adenocardnoma of the lung


Publisher
Springer-Verlag
Year
2001
Tongue
English
Weight
203 KB
Volume
170
Category
Article
ISSN
1863-4362

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K-ras mutations in human adenocarcinoma
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## Abstract We investigated point mutational activation of the __ras__ genes (K‐__ras__ codons 12, 13 and 61; N‐__ras__ codons 12, 13 and 61; H‐__ras__ codons 12 and 61) in primary, resected lung cancer by dot blotting and oligonucleotide hybridization. K‐__ras__ mutations were found in 14 (29%) of