𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Cigarette smoking and Parkinson's disease: A case–control study in a population characterized by a high prevalence of pesticide exposure

✍ Scribed by Jean-Philippe Galanaud; Alexis Elbaz; Jacqueline Clavel; Jean-Sébastien Vidal; Jean-René Corrèze; Annick Alpérovitch; Christophe Tzourio

Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
82 KB
Volume
20
Category
Article
ISSN
0885-3185

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Epidemiological studies have been consistent in showing that cigarette smoking is inversely associated with Parkinson's disease (PD), whereas pesticide use is positively associated with PD. However, the relationship between PD and cigarette smoking remains poorly understood. Our objective was to study the relationship between cigarette smoking and PD in a population characterized by a high prevalence of pesticide exposure. This case–control study was carried out among subjects enrolled in the Mutualité Sociale Agricole, the French health insurance organization for workers connected to the agricultural world. We included 247 cases and 676 controls matched on age, sex, and region of residency. Information on smoking was obtained through in‐person interviews. Pesticide exposure was assessed using a case‐by‐case expert evaluation procedure. We found an inverse relationship between ever cigarette smoking and PD (odds ratio [OR] = 0.6; 95% confidence interval [CI] = 0.4–0.9). The strength of this association increased with the number of pack‐years. This relationship was present even when smoking was considered as long as 40 years before PD onset. An inverse association was also present among subjects professionally exposed to pesticides (OR = 0.5; 95% CI = 0.3–0.8) and was independent of the duration of exposure among men. We confirm the inverse association between cigarette smoking and PD in a population characterized by a high prevalence of professional pesticide exposure. The relationship between PD and cigarette smoking was not significantly modified or confounded by exposure to pesticides. © 2004 Movement Disorder Society

📜 SIMILAR VOLUMES

Chemical exposures and Parkinson's disea
Chemical exposures and Parkinson's disease: A population-based case–control study
✍ Roberta Frigerio; Kevin R. Sanft; Brandon R. Grossardt; Brett J. Peterson; Alexi 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 61 KB 👁 2 views

## Abstract The putative association between pesticide exposures and Parkinson's disease (PD) remains controversial. We identified all subjects who developed PD in Olmsted County, Minnesota, from 1976 through 1995, and matched them by age (± 1 year) and sex to general population controls. We assess

Exposure to well water and pesticides in
Exposure to well water and pesticides in Parkinson's disease: A case-control study in the madrid area
✍ Félix Javier Jiménez-Jiménez; Dolores Mateo; Santiago Giménez-Roldán 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 English ⚖ 342 KB 👁 1 views

## Abstract Past exposure to well water and pesticides was assessed in 128 unselected Parkinson's disease (PD) patients and 256 age and sex‐matched controls. All were residents in a defined urban area of Madrid, Spain. In keeping with other reports, we found that exposure to well water might be a f

Monoamine oxidase B polymorphism, cigare
Monoamine oxidase B polymorphism, cigarette smoking and risk of Parkinson's disease: A study in an Asian population
✍ Tan, E.K. ;Chai, A. ;Lum, S.Y. ;Shen, H. ;Tan, C. ;Teoh, M.L. ;Yih, Y. ;Wong, M. 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 59 KB 👁 3 views

## Abstract Cigarette smoking is associated with reduced monoamine oxidase B (MAO B) activity. Polymorphisms of the __MAO B__ gene may modify the relationship between smoking and Parkinson's Disease (PD). We examined the association of MAO B intron 13 G/A polymorphism and risk of PD, and the modula

Premorbid smoking, alcohol consumption,
Premorbid smoking, alcohol consumption, and coffee drinking habits in Parkinson's disease: A case-control study
✍ Dr. Félix Javier Jiméanez-Jiméanez; Dolores Mateo; Santigo Giméanez-Roldan 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 English ⚖ 453 KB 👁 1 views

## Abstract A number of studies have reported lower cigarette consumption in patients with Parkinson's disease (PD) previous to onset of the disease. In an attempt to determine whether there existed a “premorbid attitude” by patients against the use of socially accepted “drugs,” the premorbid tobac

Cigarette smoking and prostate cancer: N
Cigarette smoking and prostate cancer: No relation with six measures of lifetime smoking habits in a large case-control study among U.S. Whites
✍ Lumey, L.H.; Pittman, B.; Zang, E.A.; Wynder, E.L. 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 34 KB 👁 3 views

## Background: The study was undertaken to describe the association between lifetime cigarette smoking habits and prostate cancer. whereas most case-control and cohort studies report no association, the positive findings from some large cohort studies are difficult to ignore. the available informat